Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells

被引：18

作者：

Egusa, H

Nikawa, H

Makihira, S

Jewett, A

Yatani, H

Hamada, T

机构：

[1] Hiroshima Univ, Dept Prosthet Dent, Grad Sch Biomed Sci, Minami Ku, Hiroshima, Japan

[2] Osaka Univ, Dept Fixed Prosthodont, Grad Sch Dent, Suita, Osaka 5650871, Japan

[3] Univ Calif Los Angeles, Sch Dent, Jane & Jerry Weintraub Ctr Reconstruct Biotechnol, Los Angeles, CA 90024 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 01期

关键词：

D O I：

10.1128/IAI.73.1.622-626.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.

引用

页码：622 / 626

页数：5

共 34 条

[1] THE BINDING-SITE ON ICAM-1 FOR PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES OVERLAPS, BUT IS DISTINCT FROM, THE LFA-1-BINDING SITE [J].