Differential patterns of c-fos mRNA expression in the amygdaloid nuclei induced by chemical somatic and visceral noxious stimuli in rats

被引:72
作者
Nakagawa, T [1 ]
Katsuya, A [1 ]
Tanimoto, S [1 ]
Yamamoto, J [1 ]
Yamauchi, Y [1 ]
Minami, M [1 ]
Satoh, M [1 ]
机构
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan
关键词
visceral pain; somatic pain; c-fos mRNA; central nucleus of amygdala; basolateral nucleus of amygdala; formalin; acetic acid;
D O I
10.1016/S0304-3940(03)00465-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Pain includes a negative affective component, although the neural system is unclear. The amygdala including the lateral (La), basolateral (BL) and central (Ce) nuclei is thought to play a key role in emotional responses. In this study, we analyzed the c-fos mRNA expression, as a marker of neuronal activity, induced by two types of pain, chemical somatic and visceral noxious stimuli, in each amygdaloid nucleus in unanesthetized rats. We found that intraplantar injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the La and BL, but not Ce. On the other hand, intraperitoneal injection of acetic acid as a chemical visceral noxious stimulus induced it highly in the Ce, moderately in La and hardly in BL. These results suggest that distinct amygdaloid nuclei are activated by chemical somatic and visceral noxious stimuli, which might differentially contribute to emotional responses by them. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:197 / 200
页数:4
相关论文
共 21 条
[1]   COLUMNAR ORGANIZATION IN THE MIDBRAIN PERIAQUEDUCTAL GRAY - MODULES FOR EMOTIONAL EXPRESSION [J].
BANDLER, R ;
SHIPLEY, MT .
TRENDS IN NEUROSCIENCES, 1994, 17 (09) :379-389
[2]   THE PARABRACHIAL AREA - ELECTROPHYSIOLOGICAL EVIDENCE FOR AN INVOLVEMENT IN VISCERAL NOCICEPTIVE PROCESSES [J].
BERNARD, JF ;
HUANG, GF ;
BESSON, JM .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (05) :1646-1660
[3]  
Bernard JF, 1996, PROG BRAIN RES, V107, P243
[4]  
BERNARD JF, 1992, J NEUROPHYSIOL, V68, P551
[5]  
Burstein R, 1996, PROG BRAIN RES, V107, P257
[6]  
Crown ED, 2000, BEHAV NEUROSCI, V114, P561
[7]   The amygdala and emotion [J].
Gallagher, M ;
Chiba, AA .
CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (02) :221-227
[8]   Using c-fos as a neural marker of pain [J].
Harris, JA .
BRAIN RESEARCH BULLETIN, 1998, 45 (01) :1-8
[9]   Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala [J].
Killcross, S ;
Robbins, TW ;
Everitt, BJ .
NATURE, 1997, 388 (6640) :377-380
[10]  
LeDoux J E, 1992, Curr Opin Neurobiol, V2, P191, DOI 10.1016/0959-4388(92)90011-9