Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques

被引:15
作者
Kawabata, S
Miller, CJ
Lehner, T
Fujihashi, K
Kubota, M
McGhee, JR
Imaoka, K
Hiroi, T
Kiyono, H [1 ]
机构
[1] Osaka Univ, Microbial Dis Res Inst, Dept Mucosal Immunol, Suita, Osaka 565, Japan
[2] Univ Alabama, Dept Oral Biol, Birmingham, AL 35294 USA
[3] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA
[4] Univ Alabama, Immunobiol Vaccine Ctr, Birmingham, AL 35294 USA
[5] Univ Calif Davis, Calif Reg Primate Res Ctr, Davis, CA USA
[6] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Dept Immunol, London, England
[7] Osaka Univ, Fac Dent, Dept Oral Microbiol, Osaka, Japan
关键词
D O I
10.1086/513811
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine if there is an association between the isotype of simian immunodeficiency virus (SIV)-specific B cell responses and the profile of Th1 and Th2 cytokine expression, rhesus macaques were immunized with SIV antigens via the iliac lymph nodes, using a targeted lymph node (TLN) immunization procedure, When CD4(+) T cells purified from antigen-stimulated peripheral blood mononuclear cells were analyzed, the levels of Th2 cytokine production were gradually increased after the second and third immunizations, However, interferon-gamma production did not change, Analysis of SIV-specific B cell responses revealed that the main isotype was IgG after the second and third immunizations, In addition, a peak of SIV-specific IgA B cell responses was noted following the third immunization, These findings suggest that the induction of Th2 type responses in TLN-immunized rhesus macaques reflects the sequence of initial induction of SIV-specific IgG-producing cells followed by IgA-secreting cells.
引用
收藏
页码:26 / 33
页数:8
相关论文
共 34 条
  • [1] INTERLEUKINS AND IGA SYNTHESIS - HUMAN AND MURINE INTERLEUKIN-6 INDUCE HIGH-RATE IGA SECRETION IN IGA-COMMITTED B-CELLS
    BEAGLEY, KW
    ELDRIDGE, JH
    LEE, F
    KIYONO, H
    EVERSON, MP
    KOOPMAN, WJ
    HIRANO, T
    KISHIMOTO, T
    MCGHEE, JR
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) : 2133 - 2148
  • [2] BEAGLEY KW, 1988, J IMMUNOL, V141, P2035
  • [3] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [4] CHANGES IN INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION IN ASYMPTOMATIC, HUMAN IMMUNODEFICIENCY VIRUS-SEROPOSITIVE INDIVIDUALS
    CLERICI, M
    HAKIM, FT
    VENZON, DJ
    BLATT, S
    HENDRIX, CW
    WYNN, TA
    SHEARER, GM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) : 759 - 765
  • [5] COFFMAN RL, 1987, J IMMUNOL, V139, P3685
  • [6] IGA ANTIBODY-PRODUCING CELLS IN PERIPHERAL-BLOOD AFTER ANTIGEN INGESTION - EVIDENCE FOR A COMMON MUCOSAL IMMUNE-SYSTEM IN HUMANS
    CZERKINSKY, C
    PRINCE, SJ
    MICHALEK, SM
    JACKSON, S
    RUSSELL, MW
    MOLDOVEANU, Z
    MCGHEE, JR
    MESTECKY, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) : 2449 - 2453
  • [7] QUANTITATION OF HUMAN INFLUENZA VIRUS-SPECIFIC CYTOTOXIC T-LYMPHOCYTES - CORRELATION OF CYTOTOXICITY AND INCREASED NUMBERS OF IFN-GAMMA PRODUCING CD8(+) T-CELLS
    DIFABIO, S
    MBAWUIKE, IN
    KIYONO, H
    FUJIHASHI, K
    COUCH, RB
    MCGHEE, JR
    [J]. INTERNATIONAL IMMUNOLOGY, 1994, 6 (01) : 11 - 19
  • [8] WOMEN, HIV, AND MUCOSAL IMMUNITY
    FORREST, BD
    [J]. LANCET, 1991, 337 (8745) : 835 - 836
  • [9] HUMAN APPENDIX B-CELLS NATURALLY EXPRESS RECEPTORS FOR AND RESPOND TO INTERLEUKIN-6 WITH SELECTIVE IGA1 AND IGA2 SYNTHESIS
    FUJIHASHI, K
    MCGHEE, JR
    LUE, C
    BEAGLEY, KW
    TAGA, T
    HIRANO, T
    KISHIMOTO, T
    MESTECKY, J
    KIYONO, H
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (01) : 248 - 252
  • [10] LACK OF EVIDENCE FOR THE DICHOTOMY OF T(H)1 AND T(H)2 PREDOMINANCE IN HIV-INFECTED INDIVIDUALS
    GRAZIOSI, C
    PANTALEO, G
    GANTT, KR
    FORTIN, JP
    DEMAREST, JF
    COHEN, OJ
    SEKALY, RP
    FAUCI, AS
    [J]. SCIENCE, 1994, 265 (5169) : 248 - 252