Biology and pathology of nectins and nectin-like molecules

被引：119

作者：

Sakisaka, T ^{[1
]}

Takai, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2004.07.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunoglobulin-like nectins contribute to the formation of a variety of cell-cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and proliferation, and assist or modify their functions. On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated.

引用

页码：513 / 521

页数：9

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