The potential role of surgery after induction treatment

被引：14

作者：

Grunenwald, DH

Albain, KS

机构：

[1] Inst Mutualiste Montsouris, Thorac Dept, F-75014 Paris, France

[2] Loyola Univ, Ctr Med, Div Hematol Oncol, Mywood, IL USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.semradonc.2004.09.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Induction treatment is the initial therapy that is administered before any locoregional procedure. In this article, the history of preoperative chemotherapy or chemoradiotherapy followed by induction chemoradiotherapy, in locally advanced non-small cell lung cancers (stages III A and B) is discussed, as well as the selection of an optimal subset of patients for induction strategies. In addition, the prognostic effects of response to treatment and/or surgical resection as recently reported in published clinical trials are analyzed. Finally, we conclude that mediastinal nodal downstaging after induction therapy significantly improves the survival of patients who are surgically resected after induction. © 2004 Elsevier Inc. All rights reserved.

引用

页码：335 / 339

页数：5

共 44 条

[1] CONCURRENT CISPLATIN/ETOPOSIDE PLUS CHEST RADIOTHERAPY FOLLOWED BY SURGERY FOR STAGES IIIA(N2) AND IIIB NON-SMALL-CELL LUNG-CANCER - MATURE RESULTS OF SOUTHWEST-ONCOLOGY-GROUP PHASE-II STUDY-8805 [J].

ALBAIN, KS ;

RUSCH, VW ;

CROWLEY, JJ ;

RICE, TW ;

TURRISI, AT ;

WEICK, JK ;

LONCHYNA, VA ;

PRESANT, CA ;

MCKENNA, RJ ;

GANDARA, DR ;

FOSMIRE, H ;

TAYLOR, SA ;

STELZER, KJ ;

BEASLEY, KR ;

LIVINGSTON, RB .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (08) :1880-1892

[2] Concurrent cisplatin, etoposide, and chest radiotherapy in Pathologic stage IIIB non-small-cell lung cancer: A Southwest Oncology Group Phase II Study, SWOG 9019 [J].

Albain, KS ;

Crowley, JJ ;

Turrisi, AT ;

Gandara, DR ;

Farrar, WB ;

Clark, JI ;

Beasley, KR ;

Livingston, RB .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (16) :3454-3460

[3]

Albain KS, 2003, Proc Am Soc Clin Oncol, V22, P621

[4] Persistence of viable tumor cells after radiation and chemotherapy for stage IIIB non-small cell lung cancer: An early marker of treatment failure [J].

Andre, F ;

Grunewald, D ;

Le Chevalier, T .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2001, 121 (02) :403-403

[5] Survival of patients with resected N2 non-small-cell lung cancer: Evidence for a subclassification and implications [J].

Andre, F ;

Grunenwald, D ;

Pignon, JP ;

Dujon, A ;

Pujol, JL ;

Brichon, PY ;

Brouchet, L ;

Quoix, E ;

Westeel, V ;

Le Chevalier, T .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (16) :2981-2989

[6] EFFECT OF CHEMOTHERAPY ON LOCALLY ADVANCED NON-SMALL-CELL LUNG-CARCINOMA - A RANDOMIZED STUDY OF 353 PATIENTS [J].

ARRIAGADA, R ;

LECHEVALIER, T ;

QUOIX, E ;

RUFFIE, P ;

DECREMOUX, H ;

DOUILLARD, JY ;

TARAYRE, M ;

PIGNON, JP ;

LAPLANCHE, A .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (06) :1183-1190

[7] Mediastinal lymph node clearance after docetaxel-cisplatin Neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer:: A multicenter phase II trial [J].

Betticher, DC ;

Schmitz, SFH ;

Tötsch, M ;

Hansen, E ;

Joss, C ;

von Briel, C ;

Schmid, RA ;

Pless, M ;

Habicht, J ;

Roth, AD ;

Spiliopoulos, A ;

Stahel, R ;

Weder, W ;

Stupp, R ;

Egli, F ;

Furrer, M ;

Honegger, H ;

Wernli, M ;

Cerny, T ;

Ris, HB .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (09) :1752-1759

[8]

Burdett S, 1998, LANCET, V352, P257

[9] Potential impact on survival of improved tumor downstaging and resection rate by preoperative twice-daily radiation and concurrent chemotherapy in stage IIIA non-small-cell lung cancer [J].

Choi, NC ;

Carey, RW ;

Daly, W ;

Mathisen, D ;

Wain, J ;

Wright, C ;

Lynch, T ;

Grossbard, M ;

Grillo, H .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :712-722

[10] ANTERIOR TRANSCERVICAL-THORACIC APPROACH FOR RADICAL RESECTION OF LUNG-TUMORS INVADING THE THORACIC INLET [J].

DARTEVELLE, PG ;

CHAPELIER, AR ;

MACCHIARINI, P ;

LENOT, B ;

CERRINA, J ;

LADURIE, FL ;

PARQUIN, FJF ;

LAFONT, D .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1993, 105 (06) :1025-1034

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