Estimation in a Cox regression model with a change-point according to a threshold in a covariate

被引:62
作者
Pons, O [1 ]
机构
[1] INRA, Stat Lab, F-78352 Jouy En Josas, France
[2] Univ Paris 05, F-75270 Paris 06, France
关键词
asymptotic distribution; change-point; Cox regression model; hazard function; right censoring;
D O I
10.1214/aos/1051027876
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We consider a nonregular Cox model for independent and identically distributed right censored survival times, with a change-point according to the unknown threshold of a covariate. The maximum partial likelihood estimators of the parameters and the estimator of the baseline cumulative hazard are studied. We prove that the estimator of the change-point is n-consistent and the estimator of the regression parameters are n(1/2)-consistent, and we establish the asymptotic distributions of the estimators. The estimators of the regression parameters and of the baseline cumulative hazard are adaptive in the sense that they do not depend on the knowledge of the change-point.
引用
收藏
页码:442 / 463
页数:22
相关论文
共 28 条
[1]  
Andersen P. K., 2012, Statistical models based on counting processes
[2]   COX REGRESSION-MODEL FOR COUNTING-PROCESSES - A LARGE SAMPLE STUDY [J].
ANDERSEN, PK ;
GILL, RD .
ANNALS OF STATISTICS, 1982, 10 (04) :1100-1120
[3]   THE ASYMPTOTIC JOINT DISTRIBUTION OF REGRESSION AND SURVIVAL PARAMETER ESTIMATES IN THE COX REGRESSION-MODEL [J].
BAILEY, KR .
ANNALS OF STATISTICS, 1983, 11 (01) :39-48
[4]  
Billingsley P, 1968, CONVERGE PROBAB MEAS
[5]  
Breslow N. E., 1972, J. R. Stat. Soc. Ser. B. Stat. Methodol., V34, P216, DOI [10.1111/j.2517-6161.1972.tb00900.x, DOI 10.1111/J.2517-6161.1972.TB00900.X]
[6]   PARTIAL LIKELIHOOD [J].
COX, DR .
BIOMETRIKA, 1975, 62 (02) :269-276
[7]  
COX DR, 1972, J R STAT SOC B, V34, P187
[8]  
Csorgo M, 1997, LIMIT THEOREMS CHANG
[9]  
Jespersen N. C. B., 1986, 8602 U COP STAT RES
[10]  
Kleinbaum D.G.A.K.M., 1996, Survival Analysis a Self-Learning Text