Tau in neurodegenerative diseases:: Tau phosphorylation and assembly

被引：48

作者：

Avila, J ^{[1
]}

Pérez, M ^{[1
]}

Lim, F ^{[1
]}

Gómez-Ramos, A ^{[1
]}

Hernández, F ^{[1
]}

Lucas, JJ ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

NEUROTOXICITY RESEARCH | 2004年 / 6卷 / 06期

关键词：

tau; phosphorylation; assembly; Alzheimer's disease;

D O I：

10.1007/BF03033284

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment using a tau transgenic mouse model.

引用

页码：477 / 482

页数：6

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