Proteoglycans: Master modulators of paracrine fibroblast-carcinoma cell interactions

被引：7

作者：

Friedl, Andreas ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Wisconsin Inst Med Res 6051, Madison, WI 53705 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 01期

关键词：

Cancer; Proteoglycans; Extracellular matrix; Paracrine; Tumor microenvironment; Stroma; HEPARAN-SULFATE PROTEOGLYCANS; GROWTH-FACTOR-RECEPTOR; PERLECAN PROTEIN CORE; HUMAN BREAST-CANCER; BASEMENT-MEMBRANE COLLAGEN; HIGH SYNDECAN-1 EXPRESSION; TUMOR-GROWTH; IN-VIVO; PANCREATIC-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.semcdb.2009.11.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reciprocal interactions between tumor and stromal cells govern carcinoma growth and progression. Signaling functions between these cell types in the tumor microenvironment are largely carried out by secreted growth factors and cytokines. This review discusses how proteoglycans, which are abundantly present in normal and neoplastic tissues, modulate paracrine growth factor signaling events. General principles of proteoglycan involvement in paracrine signaling include stromal induction, core protein processing by proteases and growth factor binding via proteoglycan glycosaminoglycan chains or core protein domains. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：66 / 71

页数：6

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