Ethnic differences in expression of susceptibility marker(s) in rheumatic fever rheumatic heart disease patients

被引:22
作者
Kaur, S
Kumar, D
Grover, A
Khanduja, KL
Kaplan, EL
Gray, ED
Ganguly, NK
机构
[1] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA
[2] Postgrad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Chandigarh, India
[3] Postgrad Inst Med Educ & Res, Dept Cardiol, Chandigarh 160012, India
[4] Postgrad Inst Med Educ & Res, Dept Biophys, Chandigarh, India
关键词
rheumatic fever; rheumatic heart disease; monoclonal antibodies; group A streptococci; genetic influence;
D O I
10.1016/S0167-5273(98)00009-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The ability of monoclonal antibodies (MAb) against a human B lymphocyte alloantigen has been suggested to discriminate between rheumatic fever "susceptible" individuals and persons with a lower risk of developing RF. However, while such MAb have been reported to identify a majority of RF/RHD patients in some populations, a reduced discriminatory ability has been observed in others. Antigenic variation in the RF marker(s) may exist among ethnic groups which reduce the discriminatory ability of these monoclonal antibodies. We developed MAb using B lymphocytes from RF patients of North Indian ethnic origin. In this same population we compared the new MAb (PGI/MN II) with a previously described MAb of Caucasian ethnic origin (D8/17). In three groups: acute rheumatic fever patients (no evidence of previous attacks of rheumatic fever), patients with chronic rheumatic heart disease and normal controls from the same population, we found a greater discriminating ability of PGI/MNII MAb to identify Indian RF/RHD patients than with the D8/17 MAb. Further, sixty percent of 142 siblings of the RF/RHD patients were "positive" when tested with PGI/MN II. The data from these studies suggest that before such MAb can be used for identification of RF "susceptibles" in public health programs, variation among ethnic populations must be assessed. (C) 1998 Elsevier Science Ireland Ltd.
引用
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页码:9 / 14
页数:6
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