Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri

被引:282
作者
Schwarz, S
Werckenthin, C
Kehrenberg, C
机构
[1] Bundesforsch Anstalt Landwirtschaft Braunschweig, FAL, Inst Tierzucht & Tierverhalten, D-29223 Celle, Germany
[2] Univ Munich, Tierarzliche Fak, Inst Med Mikrobiol Infekt & Seuchenmed, D-80539 Munich, Germany
关键词
D O I
10.1128/AAC.44.9.2530-2533.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The 16.5-kbp plasmid pSCFS1 from Staphylococcus sciuri mediated combined resistance to chloramphenicol and florfenicol, The gene responsible for this resistance property, cfr, was cloned and sequenced. The amino acid sequence of the Cfr protein revealed no homology to known acetyltransferases or efflux proteins involved in chloramphenicol and/or florfenicol resistance or to other proteins whose functions are known.
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页码:2530 / 2533
页数:4
相关论文
共 16 条
[1]   SEQUENCE OF A STAPHYLOCOCCAL PLASMID GENE, VGA, ENCODING A PUTATIVE ATP-BINDING PROTEIN INVOLVED IN RESISTANCE TO VIRGINIAMYCIN A-LIKE ANTIBIOTICS [J].
ALLIGNET, J ;
LONCLE, V ;
ELSOLH, N .
GENE, 1992, 117 (01) :45-51
[2]  
Arcangioli MA, 1999, FEMS MICROBIOL LETT, V174, P327, DOI 10.1016/S0378-1097(99)00161-5
[3]   Antibiotic resistance as a stress response:: Complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin [J].
De Lencastre, H ;
Wu, SW ;
Pinho, MG ;
Ludovice, AM ;
Filipe, S ;
Gardete, S ;
Sobral, R ;
Gill, S ;
Chung, M ;
Tomasz, A .
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1999, 5 (03) :163-175
[4]   A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome [J].
Foulger, D ;
Errington, J .
MICROBIOLOGY-UK, 1998, 144 :801-805
[5]   Sequence analysis of the florfenicol resistance gene encoded in the transferable R-plasmid of a fish pathogen, Pasteurella piscicida [J].
Kim, EH ;
Aoki, T .
MICROBIOLOGY AND IMMUNOLOGY, 1996, 40 (09) :665-669
[6]  
Kloos W., 1986, Bergey's manual of systematic bacteriology, V2 -, P1013
[7]  
Lodder G, 1997, FEMS IMMUNOL MED MIC, V18, P7, DOI 10.1111/j.1574-695X.1997.tb01022.x
[8]   TRANSLATIONAL ATTENUATION AS THE REGULATOR OF INDUCIBLE CAT GENES [J].
LOVETT, PS .
JOURNAL OF BACTERIOLOGY, 1990, 172 (01) :1-6
[9]  
Murray IA, 1997, ANTIMICROB AGENTS CH, V41, P1
[10]   UDDER INFECTION OF GOATS BY COAGULASE-NEGATIVE STAPHYLOCOCCI [J].
POUTREL, B .
VETERINARY MICROBIOLOGY, 1984, 9 (02) :131-137