Overview of extracellular microvesicles in drug metabolism

被引：38

作者：

Conde-Vancells, Javier ^{[1
]}

Gonzalez, Esperanza ^{[1
]}

Lu, Shelly C. ^{[2
]}

Mato, Jose M. ^{[1
]}

Falcon-Perez, Juan M. ^{[1
]}

机构：

[1] CIBERehd, CICbioGUNE, Metab Unit, Bizkaia 48160, Spain

[2] Univ So Calif, Keck Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA

来源：

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2010年 / 6卷 / 05期

关键词：

CELL-DERIVED EXOSOMES; HUMAN-SERUM-ALBUMIN; PROTEIN-PROTEIN INTERACTIONS; CYTOCHROMES P450; PROTEOMIC ANALYSIS; UDP-GLUCURONOSYLTRANSFERASES; CIRCULATING MICROPARTICLES; RETICULOCYTE MATURATION; MULTIVESICULAR BODIES; ENDOTHELIAL-CELLS;

D O I：

10.1517/17425251003614766

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Areas covered in this review: A systematic bibliographic search focused on two related aspects: i) xenobiotic-metabolizing enzymes that have been detected in microvesicles (MVs); and ii) MVs that are in the blood stream or secreted by cell types with clear interactions with this fluid. What the reader will gain: A discussion of these hepatocyte-secreted vesicles along with other MVs as enzymatic carriers in the context of extrahepatic drug-metabolizing systems. Take home message: The contribution of many tissues including the liver to the MV plasma population is supported by several reports. On the other hand, many enzymes involved in the metabolism of drugs have been detected in MVs. Together, these observations support a role of hepatic-MVs in spreading the liver metabolizing activities through the body contributing in this manner to extrahepatic drug metabolism systems what could be relevant for body homeostasis and pharmaceutical interests.

引用

页码：543 / 554

页数：12

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