Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

被引：186

作者：

Chang, Shang-Hung ^{[1
,2
]}

Wu, Lung-Sheng ^{[1
,2
]}

Chiou, Meng-Jiun ^{[3
]}

Liu, Jia-Rou ^{[3
]}

Yu, Kuang-Hui ^{[4
]}

Kuo, Chang-Fu ^{[4
]}

Wen, Ming-Shien ^{[1
,2
]}

Chen, Wei-Jan ^{[1
,2
]}

Yeh, Yung-Hsin ^{[1
,2
]}

See, Lai-Chu ^{[3
,5
]}

机构：

[1] Chang Gung Univ, Taoyuan 333, Taiwan

[2] Chang Gung Mem Hosp, Dept Cardiol, Taoyuan 333, Taiwan

[3] Chang Gung Univ, Dept Publ Hlth, Coll Med, Taoyuan 333, Taiwan

[4] Chang Gung Mem Hosp, Dept Rheumatol Allergy & Immunol, Kweishan 333, Taiwan

[5] Chang Gung Univ, Mol Med Res Ctr, Biostat Core Lab, Kweishan 333, Taiwan

来源：

CARDIOVASCULAR DIABETOLOGY | 2014年 / 13卷

关键词：

Metformin; Atrial fibrillation; Myolysis; Oxidative stress; Diabetes mellitus; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; THIAZOLIDINEDIONES; INFLAMMATION; ATHEROSCLEROSIS; ACTIVATION; EXPRESSION; ADULTS; CELLS;

D O I：

10.1186/s12933-014-0123-x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the most commonly used medication for patients with DM, on AF has not been investigated. The primary aim of this study was to examine whether metformin prevented the occurrence of AF in type 2 DM patients by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated the effect of metformin on tachycardia-induced myolysis and oxidative stress in atrial cells. Methods: The study population included 645,710 patients with type 2 diabetes and not using other anti-diabetic medication from a subset of the Taiwan National Health Insurance Research Database. Of these patients, those who used metformin were categorized as the user group, and the remaining were classified as the non-user group. The time-dependent Cox's proportional hazard model was used to examine the effect of metformin on AF and the status of metformin use was treated as a time-dependent covariate. HL-1 atrial cells were paced with or without metformin, and then troponin and heavy-chain-myosin were measured as markers of myolysis. Results: After 13 years of follow-up, 9,983 patients developed AF with an incidence rate of 1.5% (287 per 100,000 person-years). After adjusting for co-morbidities and medications, metformin independently protected the diabetic patients from new-onset AF with a hazard ratio of .81 (95% confidence interval 0.76-0.86, p < 0.0001). Metformin significantly decreased the extent of pacing-induced myolysis and the production of reactive oxygen species. Conclusion: Metformin use was associated with a decreased risk of AF in patients with type 2 DM who were not using other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress.

引用

页数：8

共 31 条

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