Peptide antagonism as a mechanism for NK cell activation

被引：130

作者：

Fadda, Lena ^{[1
]}

Borhis, Gwenoline ^{[1
]}

Ahmed, Parvin ^{[1
]}

Cheent, Kuldeep ^{[1
]}

Pageon, Sophie V. ^{[2
]}

Cazaly, Angelica ^{[3
]}

Stathopoulos, Stavros ^{[1
]}

Middleton, Derek ^{[4
,5
]}

Mulder, Arend ^{[6
]}

Claas, Frans H. J. ^{[6
]}

Elliott, Tim ^{[3
]}

Davis, Daniel M. ^{[2
]}

Purbhoo, Marco A. ^{[1
]}

Khakoo, Salim I. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Med, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Med, London W2 1PG, England

[3] Univ Southampton, Southampton Gen Hosp, Canc Sci Div, Southampton SO16 6YD, Hants, England

[4] Royal Liverpool Univ Hosp, Liverpool L7 8XP, Merseyside, England

[5] Univ Liverpool, Sch Infect & Immun, Liverpool L7 8XP, Merseyside, England

[6] Leiden Univ, Med Ctr, Dept Immunohaematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 22期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

killer cell immunoglobulin-like receptors; MHC class I; MHC CLASS-I; INHIBITORY RECEPTOR GENES; IMMUNOGLOBULIN-LIKE RECEPTOR; C VIRUS-INFECTION; COMPLEX CLASS-I; HLA CLASS-I; MEDIATED LYSIS; DIRECT BINDING; CUTTING EDGE; RECOGNITION;

D O I：

10.1073/pnas.0913745107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.

引用

页码：10160 / 10165

页数：6

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