Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams

被引：89

作者：

Kobayashi, Yusuke

Kamisaki, Haruhi

Takeda, Hiroshi

Yasui, Yoshizumi

Yanada, Reiko

Takemoto, Yoshiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Hiroshima 7370112, Japan

来源：

TETRAHEDRON | 2007年 / 63卷 / 14期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.tet.2007.01.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Pd(0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1,1-disubstituted alkenyl cyanoformamides, the Pd(0)-catalyzed C-CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the beta-position in good yields. The mechanism of the reaction was also discussed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2978 / 2989

页数：12

共 66 条

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