Adenosine in fibrosis

被引：40

作者：

Chan, Edwin S. L. ^{[1
]}

Cronstein, Bruce N. ^{[1
]}

机构：

[1] NYU, Sch Med, Clin & Translat Sci Inst, New York, NY 10016 USA

来源：

MODERN RHEUMATOLOGY | 2010年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Adenosine receptor; Fibrosis; Collagen; Cirrhosis; HEPATIC STELLATE CELLS; SYSTEMIC LUPUS-ERYTHEMATOSUS; SUPEROXIDE ANION GENERATION; PROTEIN-KINASE-A; EXTRACELLULAR ADENOSINE; TNF-ALPHA; PHYSIOLOGICAL MODULATOR; PULMONARY INFLAMMATION; ALKALINE-PHOSPHATASE; DEAMINASE DEFICIENCY;

D O I：

10.1007/s10165-009-0251-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regenerative responses are intricately linked, with wound healing being a prime example. It has only recently been appreciated that adenosine has a key role in tissue regenerative and fibrotic processes. An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently.

引用

页码：114 / 122

页数：9

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