The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups

被引：46

作者：

Cook, MA ^{[1
]}

Moss, PAH

Briggs, DC

机构：

[1] Natl Blood Serv, Dept Histocompatibil & Immunogenet, Birmingham B15 2SG, W Midlands, England

[2] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 2003年 / 30卷 / 03期

关键词：

D O I：

10.1046/j.1365-2370.2003.00394.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Killer-cell immunoglobulin-like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction-sequence-specific primers (PCR-SSP) method for typing KIRs using genomic DNA, we compared KIR frequencies in three ethnic populations drawn from UK blood donors. We found a significantly lower frequency of the inhibitory KIRs KIR2DS1 and 3DS1 in Afro-Caribbean blood donors. Despite this, there was a (non-significant) increase in the B haplotype in Afro-Caribbean and Indian Asian donors. Some donors from each group tested negative for all non-inhibitory KIRs. In addition, we describe several new KIR profiles. Analysis of linkage disequilibrium was consistent with previously published findings.

引用

页码：213 / 221

页数：9

共 23 条

[1]

Baur M.P., 1980, HISTOCOMPATIBILITY T, P955

[2] A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines [J].

Cook, MA ;

Norman, PJ ;

Curran, MD ;

Maxwell, LD ;

Briggs, DC ;

Middleton, D ;

Vaughan, RW .

HUMAN IMMUNOLOGY, 2003, 64 (05) :567-571

[3] Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires [J].

Crum, KA ;

Logue, SE ;

Curran, MD ;

Middleton, D .

TISSUE ANTIGENS, 2000, 56 (04) :313-326

[4] Human natural killer cell inhibitory receptors bind to HLA class I molecules [J].

Dohring, C ;

Colonna, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (02) :365-369

[5] Genotyping of human killer-cell immunoglobulin-like receptor genes by polymerase chain reaction with sequence-specific primers:: An update [J].

Gómez-Lozano, N ;

Vilches, C .

TISSUE ANTIGENS, 2002, 59 (03) :184-193

[6] Killer Ig-like receptor haplotype analysis by gene content: Evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets [J].

Hsu, KC ;

Liu, XR ;

Selvakumar, A ;

Mickelson, E ;

O'Reilly, RJ ;

Dupont, B .

JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :5118-5129

[7] Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans [J].

Khakoo, SI ;

Rajalingam, R ;

Shum, BP ;

Weidenbach, K ;

Flodin, L ;

Muir, DG ;

Canavez, F ;

Cooper, SL ;

Valiante, NM ;

Lanier, LL ;

Parham, P .

IMMUNITY, 2000, 12 (06) :687-698

[8] NK cell receptors [J].

Lanier, LL .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :359-393

[9]

MATTIUZ PL, 1971, HISTOCOMPATIBILITY T, P193

[10] A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey [J].

Maxwell, LD ;

Wallace, A ;

Middleton, D ;

Curran, MD .

TISSUE ANTIGENS, 2002, 60 (03) :254-258

← 1 2 3 →