Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France

被引：85

作者：

Lemée, V ^{[1
]}

Zaharia, I

Nevez, G

Rabodonirina, M

Brasseur, P

Ballet, JJ

Favennec, L

机构：

[1] CHU Charles Nicolle, Lab Parasitol Expt, F-76031 Rouen, France

[2] CHU Amiens Sud, Parasitol Lab, F-80054 Amiens 1, France

[3] Hop Edouard Herriot, Parasitol Lab, F-69373 Lyon, France

[4] CHU Clemenceau, Lab Immunol & Immunopathol, F-14033 Caen, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 46卷 / 05期

关键词：

D O I：

10.1093/jac/46.5.819

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days), All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.

引用

页码：819 / 821

页数：3

共 11 条

[1] THE ACTIVITY OF AZITHROMYCIN AGAINST STOCKS OF GIARDIA-INTESTINALIS INVITRO AND INVIVO [J].

BOREHAM, PFL ;

UPCROFT, JA .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) :620-621

[2] THE ACTIVITY OF DRUGS AGAINST GIARDIA-INTESTINALIS IN NEONATAL MICE [J].

BOREHAM, PFL ;

PHILLIPS, RE ;

SHEPHERD, RW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 18 (03) :393-398

[3]

BRASSEUR P, 1995, PARASITE, V2, P422

[4] SEXUAL STAGE DEVELOPMENT OF CRYPTOSPORIDIA IN THE CACO-2 CELL-LINE [J].

BURAUD, M ;

FORGET, E ;

FAVENNEC, L ;

BIZET, J ;

GOBERT, JG ;

DELUOL, AM .

INFECTION AND IMMUNITY, 1991, 59 (12) :4610-4613

[5] Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico [J].

Cabello, RR ;

Guerrero, LR ;

Garcia, MDM ;

Cruz, AG .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1997, 91 (06) :701-703

[6]

CHOCHILLON C, 1990, CR SOC BIOL, V184, P150

[7] ADHERENCE AND MULTIPLICATION OF GIARDIA-INTESTINALIS ON HUMAN ENTEROCYTE-LIKE DIFFERENTIATED CELLS-INVITRO [J].

FAVENNEC, L ;

CHOCHILLON, C ;

MEILLET, D ;

MAGNE, D ;

SAVEL, J ;

RAICHVARG, D ;

GOBERT, JG .

PARASITOLOGY RESEARCH, 1990, 76 (07) :581-584

[8] COMPARISON OF AN INVITRO METHOD AND AN INVIVO METHOD OF GIARDIA EXCYSTATION [J].

ISAACRENTON, JL ;

SHAHRIARI, H ;

BOWIE, WR .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1992, 58 (05) :1530-1533

[9] CRYOPRESERVATION OF VIABLE GIARDIA-INTESTINALIS TROPHOZOITES [J].

PHILLIPS, RE ;

BOREHAM, PFL ;

SHEPHERD, RW .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1984, 78 (05) :604-606

[10] RESISTANCE TO THE NITROHETEROCYCLIC DRUGS [J].

TOWNSON, SM ;

BOREHAM, PFL ;

UPCROFT, P ;

UPCROFT, JA .

ACTA TROPICA, 1994, 56 (2-3) :173-194

← 1 2 →