Influence of various factors on the chromatographic behavior of cytostatic antibiotics of rubomicin derivatives in micellar liquid chromatography

被引：11

作者：

Kulikov, AU

Loginova, LP

Samokhina, LV

机构：

[1] Sci & Expert Pharmacopoeial Ctr, Lab Pharmacopoeial Anal, UA-61085 Kharkov, Ukraine

[2] VN Karazin Kharkov Natl Univ, Dept Chem Metrol, UA-61077 Kharkov, Ukraine

来源：

CHROMATOGRAPHIA | 2003年 / 57卷 / 7-8期

关键词：

column liquid chromatography; micellar chromatography; sodium dodecyl sulfate; cytostatic antibiotics of rubomicin derivatives;

D O I：

10.1007/BF02492542

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Micellar liquid chromatography has been adopted for separation of cytostatic antibiotics of rubomicin derivatives. The influence of the kind of organic modifier (normal and iso-alcohols) and its concentration, sodium dodecyl sulfate micelle concentration and column temperature on the chromatographic characteristics of rubomicin derivatives have been investigated. 1-pentanol and iso-propanol were shown to be the most suitable for providing optimum selectivity, good tailing factor and column efficiency with minimum reagent consumption.

引用

页码：463 / 469

页数：7

共 17 条

[1] USE OF AN AQUEOUS MICELLAR MOBILE PHASE FOR SEPARATION OF PHENOLS AND POLYNUCLEAR AROMATIC-HYDROCARBONS VIA HPLC [J].