Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

被引:93
作者
Horvat, Jay C. [1 ,2 ]
Starkey, Malcolm R. [1 ,2 ]
Kim, Richard Y. [1 ,2 ]
Phipps, Simon [1 ,2 ]
Gibson, Peter G. [1 ,2 ]
Beagley, Kenneth W. [3 ]
Foster, Paul S. [1 ,2 ]
Hansbro, Philip M. [1 ,2 ]
机构
[1] Univ Newcastle, Ctr Asthma & Resp Dis, Callaghan, NSW 2308, Australia
[2] Univ Newcastle, Hunter Med Res Inst, Callaghan, NSW 2308, Australia
[3] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove, Qld, Australia
基金
澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
Asthma; Chlamydia; immunologic programming; lung structure; dendritic cell; IL-13; infant; neonate; lung function; MYELOID DENDRITIC CELLS; AIR-FLOW LIMITATION; PNEUMONIAE INFECTION; ASTHMA; IMMUNITY; RESPONSES; INFLAMMATION; CHILDHOOD; ANTIGEN; VIRUS;
D O I
10.1016/j.jaci.2009.10.018
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Asthma typically originates in early-life, and the impact of infection during immunologic, maturation is a critical factor in disease pathogenesis. The progression of aberrant T(H)2 cell responses and disease development has been attributed to a lack of infections. However, exposure to specific pathogens such as Chlamydia may alter immunologic programming and predispose to asthma. Objective: To investigate the effects of chlamydial infection at different ages on allergic airways disease in later life. Methods: Neonatal, infant, or adult BALB/c mice were infected and 6 weeks later were sensitized and subsequently challenged with ovalbumin. Hallmark features of allergic airways disease were compared with uninfected allergic and nonallergic controls. Results: Early-life (neonatal and infant) but not adult chlamydial infection enhanced the development of hallmark features of asthma in ovalbumin-induced allergic airways disease. Notably early-life infection increased mucus-secreting cell numbers, IL-13 expression, and airway hyperresponsiveness. Neonatal infection attenuated eosinophil influx and ovalbumin-specific T(H)2 cytokine release and numbers of activated myeloid dendritic cells (DCs) in lymph nodes. By contrast, infant infection augmented features of allergic inflammation with increased airway eosinophils, T(H)2 cytokine, and DC responses. Both neonatal and infant infection increased systemic DC-induced IL-13 release from CD4(+) T cells. The timing of infection had significant effects on lung structure because neonatal but not infant or adult infection induced increases in alveolar diameter. Conclusion: Early-life respiratory chlamydial infections modulate immune responses, alter lung function and structure, and enhance the severity of allergic airways disease in later life. (J Allergy Clin Immunol 2010;125:617-25.)
引用
收藏
页码:617 / 625
页数:9
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