4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials

被引：124

作者：

Verotta, L

Lovaglio, E

Vidari, G

Finzi, PV

Neri, MG

Raimondi, A

Parapini, S

Taramelli, D

Riva, A

Bombardelli, E

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy

[3] Univ Milan, Ist Microbiol, I-20133 Milan, Italy

[4] Indena SpA, I-20139 Milan, Italy

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 21期

关键词：

Mesua ferrea; Guttiferae; 4-alkyl and 4-phenyl 5,7-dihydroxycoumarins;

D O I：

10.1016/j.phytochem.2004.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Supercritical CO2 selectively extracted a series of 4-alkyl and 4-phenyl 5,7-dihydroxycoumarins from Mesua ferrea blossoms. Chemical modifications of the isolated compounds allowed us to confirm the structures elucidated by spectroscopic means and to prepare new derivatives amenable to SAR studies and potential pharmaceutical development. Biological investigations towards the screening on a number of bacteria strains and Plasmoditunftilciparum, identified compounds 1-9 as weak antiprotozoal agents and potent antibacterials on resistant Gram-positive strains. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2867 / 2879

页数：13

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