Kumada-Corriu coupling of Grignard reagents, probed with a chiral Grignard reagent

被引：74

作者：

Hölzer, B ^{[1
]}

Hoffmann, RW ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 06期

关键词：

D O I：

10.1039/b300033h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Grignard reagent 2, in which the magnesium-bearing carbon atom is the sole stereogenic centre has been coupled with vinyl bromide under Pd(0) or Ni(0)-catalysis to give compound 3 with full retention of configuration. Coupling using Fe(acac)(3) or Co(acac)(2) as catalyst was accompanied by considerable racemisation. These findings are discussed with respect to a dichotomy between concerted polar and stepwise SET transmetallation pathways.

引用

页码：732 / 733

页数：2

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