Variability of the subthalamic nucleus: The case for direct MRI guided targeting

被引:95
作者
Ashkan, K.
Blomstedt, P.
Zrinzo, L.
Tisch, S.
Yousry, T.
Limousin-Dowsey, P.
Hariz, M. I.
机构
[1] Inst Neurol, Unit Funct Neurosurg, London WC1N 3BG, England
[2] Inst Neurol, Dept Neuroradiol, London WC1N 3BG, England
[3] Univ Hosp, Dept Neurosurg, Umea, Sweden
关键词
deep brain stimulation; direct targeting; magnetic resonance imaging; Parkinson's disease; subthalamic nucleus;
D O I
10.1080/02688690701272240
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Because of concerns about direct visualization of the subthalamic nucleus (STN) on magnetic resonance imaging ( MRI), many functional neurosurgeons continue to rely on atlas-based coordinates to reach this target. T2-weighted MRI does allow direct visualisation of the STN. In order to compare the coordinates of the target point within the visualised STN with those obtained from standard brain atlases, the preoperative stereotactic T2- weighted MRI used to implant 55 deep brain stimulation electrodes in the visualised STN of 29 consecutive patients with Parkinson's disease treated in two European centres were studied. The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus.
引用
收藏
页码:197 / 200
页数:4
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