Morphological evidence for neural interactions between leptin and orexin in the hypothalamus

被引：49

作者：

Funahashi, H ^{[1
]}

Hori, T

Shimoda, Y

Mizushima, H

Ryushi, T

Katoh, S

Shioda, S

机构：

[1] Showa Univ, Sch Med, Dept Anat, Tokyo 1428555, Japan

[2] Tokyo Metropolitan Univ, Grad Sch Sci, Dept Kinesiol, Tokyo 1920364, Japan

来源：

REGULATORY PEPTIDES | 2000年 / 92卷 / 1-3期

基金：

日本科学技术振兴机构;

关键词：

leptin; leptin receptor; orexin; hypothalamus; food intake; immunohistochemistry;

D O I：

10.1016/S0167-0115(00)00146-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both leptin and orexin have been recently discovered as peptides involved in feeding regulation. The morphological evidence of neural interaction between leptin and orexin, one considered to inhibit food intake and the other to stimulate it in the central nervous system (CNS), was studied by use of double immunostaining method. The leptin receptor-like immunoreactive (LR-LI) neurons in the hypothalamic arcuate nucleus and ventromedial nucleus were innervated by orexin-like immunoreactive (OX-LI) neurons. The distribution of LR-LI neurons in the hypothalamus was very similar to that of OX-LI neurons. These results may suggest that leptin and orexin are intimately correlated with each other and that they reciprocally regulate feeding at the hypothalamic level. (C) 2000 Published by Elsevier Science B.V.

引用

页码：31 / 35

页数：5

共 36 条

[1] SPECIFIC-INHIBITION OF ENDOGENOUS NEUROPEPTIDE-Y SYNTHESIS IN ARCUATE NUCLEUS BY ANTISENSE OLIGONUCLEOTIDES SUPPRESSES FEEDING-BEHAVIOR AND INSULIN-SECRETION [J].