Mechanistic aspects - the dioxin (aryl hydrocarbon) receptor

被引：54

作者：

Poellinger, L ^{[1
]}

机构：

[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

来源：

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2000年 / 17卷 / 04期

关键词：

Ah receptor; ligand binding; molecular targets; physiological function; receptor conformation; signal transduction;

D O I：

10.1080/026520300283333

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The Ah receptor mediates the toxicological responses of 2,3,7,8-TCDD and related compounds. Receptor-deficient animals were shown to be resistant to the toxic effects of dioxin, although there is also evidence for the existence of a receptor-independent pathway for dioxin-induced toxicity. In the cytosol the receptor is present in a non-activated ligand binding conformation. Association with Arnt in the nucleus turns the receptor complex into a ligand activated form. The physiological role of the receptor is not yet understood, however, the conservation of the receptor in a wide range of animal species (including humans) suggests a fundamental Pole in cellular physiology.

引用

页码：261 / 266

页数：6

共 66 条

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