Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses

被引：30

作者：

Bourreau, E

Gardon, J

Pradinaud, R

Pascalis, H

Prévot-Linguet, G

Kariminia, A

Pascal, L

机构：

[1] Inst Pasteur, Serv Epidemiol, Cayenne 97306, French Guiana

[2] Ctr Hosp Andree Rosemon, EA 2188, Inst Guyanais Dermatol Trop, Cayenne, French Guiana

[3] Univ Antilles Guyane, Inst Enseignement Super Guyane, Cayenne, French Guiana

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期

关键词：

D O I：

10.1128/IAI.71.4.2244-2246.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression.

引用

收藏

页码：2244 / 2246

页数：3

相关论文

共 16 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice [J].

Biedermann, T ;

Zimmermann, S ;

Himmelrich, H ;

Gumy, A ;

Egeter, A ;

Sakrauski, AK ;

Seegmüller, I ;

Voigt, H ;

Launois, P ;

Levine, AD ;

Wagner, H ;

Heeg, K ;

Louis, JA ;

Röcken, M .

NATURE IMMUNOLOGY, 2001, 2 (11) :1054-1060

[3] Interleukin (IL)-13 is the predominant th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12 [J].

Bourreau, E ;

Prévot, G ;

Pradinaud, R ;

Launois, P .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (06) :953-959

[4]

CACERESDITTMAR G, 1993, CLIN EXP IMMUNOL, V91, P500, DOI 10.1111/j.1365-2249.1993.tb05931.x

[5]

Chico M E, 1995, Rev Soc Bras Med Trop, V28, P99, DOI 10.1590/S0037-86821995000200002

[6] MACROPHAGE ACTIVATION BY INTERFERON-GAMMA FROM HOST-PROTECTIVE T-CELLS IS INHIBITED BY INTERLEUKIN (IL)3 AND IL4 PRODUCED BY DISEASE-PROMOTING T-CELLS IN LEISHMANIASIS [J].

LIEW, FY ;

MILLOTT, S ;

LI, Y ;

LELCHUK, R ;

CHAN, WL ;

ZILTENER, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (07) :1227-1232

[7] Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major [J].

Louzir, H ;

Melby, PC ;

Ben Salah, A ;

Marrakchi, H ;

Aoun, K ;

Ben Ismail, R ;

Dellagi, K .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (06) :1687-1695

[8]

MOSMANN TR, 1989, ANNU REV IMMUNOL, V7, P145, DOI 10.1146/annurev.iy.07.040189.001045

[9] LYMPHOCYTE-RESPONSES AND CYTOKINES [J].

PAUL, WE ;

SEDER, RA .

CELL, 1994, 76 (02) :241-251

[10] CYTOKINE PATTERNS IN THE PATHOGENESIS OF HUMAN LEISHMANIASIS [J].

PIRMEZ, C ;

YAMAMURA, M ;

UYEMURA, K ;

PAESOLIVEIRA, M ;

CONCEICAOSILVA, F ;

MODLIN, RL .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1390-1395