Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

被引：21

作者：

Reichel, PH

Seemann, C

Csernok, E

Schröder, JM

Müller, A

Gross, WL

Schultz, H

机构：

[1] Univ Hosp Luebeck, Dept Rheumatol, D-24576 Bad Bramstedt, Germany

[2] Rheumaklin Bad Branstedt, D-24576 Bad Bramstedt, Germany

[3] Univ Hosp Kiel, Dept Dermatol, D-24105 Kiel, Germany

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003年 / 10卷 / 03期

关键词：

D O I：

10.1128/CDLI.10.3.473-475.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.

引用

页码：473 / 475

页数：3

共 15 条

[1] Bacterial lipopolysaccharides and innate immunity [J].