Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

被引：53

作者：

McCarron, MO

Weir, CJ

Muir, KW

Hoffmann, KL

Graffagnino, C

Nicoll, JAR

Lees, KR

Alberts, MJ

机构：

[1] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland

[2] Univ Glasgow, Western Infirm, Gardiner Inst, Acute Stroke Unit,Univ Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

[3] So Gen Hosp, Inst Neurol Sci, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland

[4] Duke Univ, Med Ctr, Dept Med, Div Neurol, Durham, England

[5] Univ Southampton, Dept Neuropathol, Southampton, Hants, England

[6] Northwestern Univ, Sch Med, Dept Neurol MJA, Chicago, IL 60611 USA

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2003年 / 107卷 / 02期

关键词：

intracerebral haemorrhage; apolipoprotein E; survival; outcome;

D O I：

10.1034/j.1600-0404.2003.01365.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective - To determine the relationship between the apolipoprotein E (APOE ) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE epsilon4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE epsilon4 allele in this population may be associated with poor survival following ICH.

引用

页码：106 / 109

页数：4

共 20 条

[1] APOE GENOTYPE AND SURVIVAL FROM INTRACEREBRAL HEMORRHAGE [J].