Visualization of metabolite identifier information

被引:3
作者
Matsuda, Fumio [1 ]
Redestig, Henning [1 ]
Sawada, Yuji [1 ]
Shinbo, Yoko [2 ]
Hirai, Masami Yokota [1 ,3 ]
Kanaya, Shigehiko [1 ,2 ]
Saito, Kazuki [1 ,4 ]
机构
[1] RIKEN Plant Sci Ctr, Kanagawa 2300045, Japan
[2] Nara Inst Sci & Technol, Grad Sch Informat Sci, Nara 6300101, Japan
[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan
[4] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba 2638522, Japan
关键词
Graph theory; metabolite identifier; plant metabolomics; INTERACTION NETWORKS; METABOLOMICS; ENVIRONMENT; ALGORITHM; DATABASE;
D O I
10.5511/plantbiotechnology.26.479
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In this study, we used a graphical representation to integrate, visualize, search, and analyze information on metabolite identifiers. By considering the links between metabolite identifiers described in the metabolite databases to be the edges between vertices in a graph, several metabolite databases can be integrated into a database without defining a new metabolite identifier code. The graphical visualization of metabolite identifier network enables us to understand the meaning of each metabolite identifier and their relationship with associated identifiers. The projection of actual metabolome data on the pathway map was also attained by using the converter function of the metabolite identifier database. We demonstrated that other metabolite-related information, such as chemical ontology and species-metabolite relationship, can be incorporated into the network, and performed an analysis of plant species-alkaloid ontology relationship.
引用
收藏
页码:479 / 483
页数:5
相关论文
共 12 条
[1]  
Akiyama Kenji, 2008, In Silico Biology, V8, P339
[2]   Development and implementation of an algorithm for detection of protein complexes in large interaction networks [J].
Altaf-Ul-Amin, Md ;
Shinbo, Yoko ;
Mihara, Kenji ;
Kurokawa, Ken ;
Kanaya, Shigehiko .
BMC BIOINFORMATICS, 2006, 7 (1)
[3]   A linear-time algorithm for computing inversion distance between signed permutations with an experimental study [J].
Bader, DA ;
Moret, BME ;
Yan, M .
JOURNAL OF COMPUTATIONAL BIOLOGY, 2001, 8 (05) :483-491
[4]   ChEBI:: a database and ontology for chemical entities of biological interest [J].
Degtyarenko, Kirill ;
de Matos, Paula ;
Ennis, Marcus ;
Hastings, Janna ;
Zbinden, Martin ;
McNaught, Alan ;
Alcantara, Rafael ;
Darsow, Michael ;
Guedj, Mickael ;
Ashburner, Michael .
NUCLEIC ACIDS RESEARCH, 2008, 36 :D344-D350
[5]   Chemical Substructure Search in SQL [J].
Golovin, Adel ;
Henrick, Kim .
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2009, 49 (01) :22-27
[6]   A CHLOROPLAST-LOCALIZED LYSINE DECARBOXYLASE OF LUPINUS-POLYPHYLLUS - THE 1ST ENZYME IN THE BIOSYNTHETIC-PATHWAY OF QUINOLIZIDINE ALKALOIDS [J].
HARTMANN, T ;
SCHOOFS, G ;
WINK, M .
FEBS LETTERS, 1980, 115 (01) :35-38
[7]   KEGG for linking genomes to life and the environment [J].
Kanehisa, Minoru ;
Araki, Michihiro ;
Goto, Susumu ;
Hattori, Masahiro ;
Hirakawa, Mika ;
Itoh, Masumi ;
Katayama, Toshiaki ;
Kawashima, Shuichi ;
Okuda, Shujiro ;
Tokimatsu, Toshiaki ;
Yamanishi, Yoshihiro .
NUCLEIC ACIDS RESEARCH, 2008, 36 :D480-D484
[8]   Decoding genes with coexpression networks and metabolomics - 'majority report by precogs' [J].
Saito, Kazuki ;
Hirai, Masarni Y. ;
Yonekura-Sakakibara, Keiko .
TRENDS IN PLANT SCIENCE, 2008, 13 (01) :36-43
[9]   Widely Targeted Metabolomics Based on Large-Scale MS/MS Data for Elucidating Metabolite Accumulation Patterns in Plants [J].
Sawada, Yuji ;
Akiyama, Kenji ;
Sakata, Akane ;
Kuwahara, Ayuko ;
Otsuki, Hitomi ;
Sakurai, Tetsuya ;
Saito, Kazuki ;
Hirai, Masami Yokota .
PLANT AND CELL PHYSIOLOGY, 2009, 50 (01) :37-47
[10]   Cytoscape: A software environment for integrated models of biomolecular interaction networks [J].
Shannon, P ;
Markiel, A ;
Ozier, O ;
Baliga, NS ;
Wang, JT ;
Ramage, D ;
Amin, N ;
Schwikowski, B ;
Ideker, T .
GENOME RESEARCH, 2003, 13 (11) :2498-2504