Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

被引：47

作者：

Campillo-Gimenez, Laure ^{[1
]}

Laforge, Mireille ^{[1
]}

Fay, Michele ^{[2
]}

Brussel, Audrey ^{[3
]}

Cumont, Marie-Christine ^{[3
]}

Monceaux, Valerie ^{[3
]}

Diop, Ousmane ^{[4
]}

Levy, Yves ^{[1
,8
]}

Hurtrel, Bruno ^{[1
,3
]}

Zaunders, John ^{[5
]}

Corbeil, Jacques ^{[6
]}

Elbim, Carole ^{[1
,7
]}

Estaquier, Jerome ^{[1
,3
,8
]}

机构：

[1] INSERM, Fac Creteil Henri Mondor, U955, F-94000 Creteil, France

[2] Univ Paris 07, Fac Med, F-75018 Paris, France

[3] Inst Pasteur, Unite Physiopathol Infect Lentivirales, F-75015 Paris, France

[4] Inst Pasteur, Dakar, Senegal

[5] St Vincents Hosp, Ctr Appl Med Res, Darlinghurst, NSW 2010, Australia

[6] Univ Laval, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[7] Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, F-75006 Paris, France

[8] Hop Henri Mondor, AP HP, F-94010 Creteil, France

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

CD4(+) T-CELLS; PRIMARY SIV INFECTION; RHESUS MACAQUES; INCREASED EXPRESSION; SIVMAC251; INFECTION; IMMUNE SUPPRESSION; VIRAL REPLICATION; ADAPTIVE IMMUNITY; APOPTOSIS; ALPHA;

D O I：

10.1128/JVI.01496-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.

引用

页码：1838 / 1846

页数：9

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