Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults

被引：65

作者：

Chi, Gloria C. ^{[1
]}

Fitzpatrick, Annette L. ^{[1
,2
,3
]}

Sharma, Monisha ^{[1
]}

Jenny, Nancy S. ^{[4
]}

Lopez, Oscar L. ^{[5
]}

DeKosky, Steven T. ^{[6
,7
]}

机构：

[1] Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St,Box 357236, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Family Med, Seattle, WA 98195 USA

[3] Univ Washington, Sch Publ Hlth, Dept Global Hlth, Seattle, WA 98195 USA

[4] Univ Vermont, Sch Med, Dept Pathol & Lab Med, Burlington, VT 05405 USA

[5] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15260 USA

[6] Univ Florida, Coll Med, McKnight Brain Inst, Gainesville, FL USA

[7] Univ Florida, Coll Med, Dept Neurol, Gainesville, FL 32611 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2017年 / 72卷 / 06期

关键词：

Inflammation; Cognitive decline; Vascular; Biomarkers; Longitudinal; SERUM-AMYLOID-P; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; ALZHEIMERS-DISEASE; PENTRAXIN; METABOLIC SYNDROME; DEMENTIA; IMPAIRMENT; COMPONENT; HEALTH;

D O I：

10.1093/gerona/glw155

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background: Vascular risk factors, including inflammation, may contribute to dementia development. We investigated the associations between peripheral inflammatory biomarkers and cognitive decline in five domains (memory, construction, language, psychomotor speed, and executive function). Methods: Community-dwelling older adults from the Ginkgo Evaluation of Memory Study (n = 1,159, aged 75 or older) free of dementia at baseline were included and followed for up to 7 years. Ten biomarkers were measured at baseline representing different sources of inflammation: vascular inflammation (pentraxin 3 and serum amyloid P), endothelial function (endothelin-1), metabolic function (adiponectin, resistin, and plasminogen activating inhibitor-1), oxidative stress (receptor for advanced glycation end products), and general inflammation (interleukin-6, interleukin-2, and interleukin-10). A combined z-score was created from these biomarkers to represent total inflammation across these sources. We utilized generalized estimating equations that included an interaction term between z-scores and time to assess effect of inflammation on cognitive decline, adjusting for demographics (such as age, race/ethnicity, and sex), cardiovascular risk factors, and apolipoprotein E e4 carrier status. A Bonferroni-adjusted significance level of.01 was used. We explored associations between individual biomarkers and cognitive decline without adjustment for multiplicity. Results: The combined inflammation z-score was significantly associated with memory and psychomotor speed (p <.01). Pentraxin 3, serum amyloid P, endothelin-1, and interleukin-2 were associated with change in at least one cognitive domain (p <.05). Conclusion: Our results suggest that total inflammation is associated with memory and psychomotor speed. In particular, systemic inflammation, vascular inflammation, and altered endothelial function may play roles in domain-specific cognitive decline of nondemented individuals.

引用

页码：796 / 803

页数：8

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