DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis

被引：85

作者：

Hoptman, MJ

Ardekani, BA

Butler, PD

Nierenberg, J

Javitt, DC

Lim, KO

机构：

[1] Nathan S Kline Inst Psychiat Res, Div Clin Res, Orangeburg, NY 10962 USA

[2] Nathan S Kline Inst Psychiat Res, Div Life Sci, Orangeburg, NY 10962 USA

[3] Nathan S Kline Inst Psychiat Res, Ctr Adv Brain Imaging, Orangeburg, NY 10962 USA

[4] NYU, Sch Med, Dept Psychiat, New York, NY USA

[5] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55454 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 16期

关键词：

diffusion tensor imaging; impulsivity; schizophrenia;

D O I：

10.1097/00001756-200411150-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Compromised white matter (WM) integrity in inferior frontal WM has been related to impulsivity in men with schizophrenia. However, these relationships may be more widespread. Fractional anisotropy (FA) derived from diffusion tensor imaging of 25 men with schizophrenia was transformed into Talairach space. Correlations between FA and impulsiveness were examined on a voxelwise basis. We found negative correlations between FA and impulsivity in inferior frontal WM, anterior cingulate, caudate, insula, and inferior parietal lobule. Positive correlations were obtained in the left postcentral gyrus, right superior/middle temporal gyrus, and bilateral fusiform gyrus. These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks.

引用

页码：2467 / 2470

页数：4

共 27 条

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