Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder

被引:15
作者
Grunewald, J
Eklund, A
Katchar, K
Moshfegh, A
Lidén, C
Lundgren, L
Skare, L
Tornling, G
机构
[1] Karolinska Hosp & Inst, Div Resp Med, Dept Med, Stockholm, Sweden
[2] Karolinska Hosp & Inst, Div Clin Immunol & Allergy, Dept Med, Stockholm, Sweden
[3] Karolinska Inst, Dept Med, S-10401 Stockholm, Sweden
[4] Stockholm Cty Council, Stockholm, Sweden
[5] Univ Stockholm, Natl Inst Working Life, S-10691 Stockholm, Sweden
[6] Univ Stockholm, ITM, S-10691 Stockholm, Sweden
[7] Astra Zeneca, Clin Sci, Lund, Sweden
关键词
bronchoalveolar lavage; cornstarch glove powder; eosinophil granulocytes;
D O I
10.1183/09031936.03.00024103
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Starch is a main component of wheat Hour, which, besides being an occupational allergen can also induce irritative symptoms in the airways. A purified starch product (cornstarch glove powder) was used to investigate whether starch alone could induce airway inflammation. The aim of the study was to investigate a role for starch in wheat flour-induced airway inflammation. Ten healthy individuals were exposed to cornstarch glove powder in a whole-body exposure chamber. Bronchoscopy with bronchoalveolar lavage (BAL) was performed 2-3 weeks before and 1 day after exposure, and the BAL cells were counted differentially. In addition, the expression of activation, adhesion and subset markers on alveolar macrophages and BAL T-cells were investigated using flow cytometry. A three-fold increase in BAL cell concentrations was found, with a selective accumulation and activation of eosinophilic granulocytes, as well as an influx of nonactivated monocytes and polyclonal CD4+ T-cells into the airways. The results show that inhalation of cornstarch glove powder leads to the development of a subclinical inflammation in the airways, with an accumulation of eosinophilic granulocytes. The authors suggest that such exposure may be an interesting model for studying factors contributing to lung accumulations of eosinophil granulocytes in humans.
引用
收藏
页码:646 / 651
页数:6
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