Regulated cutaneous gene delivery: The skin as a bioreactor

被引：22

作者：

Cao, TY

Wang, XJ

Roop, DR

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA

来源：

HUMAN GENE THERAPY | 2000年 / 11卷 / 16期

关键词：

D O I：

10.1089/104303400750035843

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic delivery of transgene products. Here we review the development of epidermal secretory systems, from cultured keratinocytes to skin grafts and transgenic mouse models. We also discuss a gene-switch approach for regulated cutaneous gene delivery.

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页码：2297 / 2300

页数：4

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