Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion

被引：21

作者：

Hazekawa, Mai ^{[1
,2
]}

Kataoka, Aiko ^{[1
]}

Hayakawa, Kazuhide ^{[1
]}

Uchimasu, Takeshi ^{[1
]}

Furuta, Riyo ^{[1
]}

Irie, Keiichi ^{[1
,3
]}

Akitake, Yoshiharu ^{[1
]}

Yoshida, Miyako ^{[2
,4
]}

Fujioka, Toshihiro ^{[4
]}

Egashira, Nobuaki ^{[5
]}

Oishi, Ryozo ^{[5
]}

Mishima, Kenji ^{[3
,6
]}

Mishima, Kenichi ^{[1
]}

Uchida, Takahiro ^{[2
]}

Iwasaki, Katunori ^{[1
,3
]}

Fujiwara, Michihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, 8-19-1 Nanakuma, Fukuoka 8140180, Japan

[2] Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Clin Pharmaceut, Nishinomiya, Hyogo 6638179, Japan

[3] Fukuoka Univ, Fac Pharmaceut Sci, Adv Mat Inst, Fukuoka 8140180, Japan

[4] Fukuoka Univ, Fac Pharmaceut Sci, Dept Instrumental Anal, Fukuoka 8140180, Japan

[5] Kyushu Univ Hosp, Dept Pharm, Higashi Ku, Fukuoka 8128582, Japan

[6] Fukuoka Univ, Dept Chem Engn, Fukuoka 8140180, Japan

来源：

JOURNAL OF HEALTH SCIENCE | 2010年 / 56卷 / 03期

关键词：

Hericium erinaceum; middle cerebral artery occlusion; nerve growth factor; cerebral ischemia; neuroprotection; OPIOID RECEPTOR AGONIST; GROWTH-FACTOR (NGF)-SYNTHESIS; CENTRAL-NERVOUS-SYSTEM; FOCAL ISCHEMIA; NITRIC-OXIDE; BLOOD-FLOW; IMPAIRMENT; MUSHROOM; MYCELIA; RAT;

D O I：

10.1248/jhs.56.296

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300 mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H. erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H. erinaceum and its components could be useful for preventing cerebral infarction.

引用

页码：296 / 303

页数：8

共 34 条

[1]

Dexamethasone enhances upregulation of nerve growth factor mRNA expression in ischemic rat brain [J].

Chang, CN ;

Yang, JT ;

Lee, TH ;

Cheng, WC ;

Hsu, YH ;

Wu, JH .

JOURNAL OF CLINICAL NEUROSCIENCE, 2005, 12 (06) :680-684

[2]

Chang R, 1996, NUTR REV, V54, pS91, DOI 10.1111/j.1753-4887.1996.tb03825.x

[3]

Prolonged opportunity for ischemic neuroprotection with selective κ-opioid receptor agonist in rats [J].

Chen, TY ;

Goyagi, T ;

Toung, TJK ;

Kirsch, JR ;

Hurn, PD ;

Koehler, RC ;

Bhardwaj, A .

STROKE, 2004, 35 (05) :1180-1185

[4]

Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl4-induced hepatic damage of HEM extract [J].

Choi, WS ;

Kim, CJ ;

Park, BS ;

Lee, SE ;

Takeoka, GR ;

Kim, DG ;

LanPiao, X ;

Kim, JH .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 100 (1-2) :176-179

[5]

Hemodynamic manipulation in the neuro-intensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm [J].

Diringer, Michael N. ;

Axelrod, Yekaterina .

CURRENT OPINION IN CRITICAL CARE, 2007, 13 (02) :156-162

[6]

Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo [J].

Edagawa, Y ;

Smriga, M ;

Nishiyama, N ;

Saito, H .

NEUROSCIENCE LETTERS, 2001, 314 (03) :139-142

[7]

Reduction of cortical infarction and impairment of apoptosis in NGF-transgenic mice subjected to permanent focal ischemia [J].

Guégan, C ;

Onténiente, B ;

Makiura, Y ;

Merad-Boudia, M ;

Ceballos-Picot, I ;

Sola, B .

MOLECULAR BRAIN RESEARCH, 1998, 55 (01) :133-140

[8]

Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism [J].

Hayakawa, Kazuhide ;

Mishima, Kenichi ;

Nozako, Masanori ;

Hazekawa, Mai ;

Mishima, Shohei ;

Fujioka, Masayuki ;

Orito, Kensuke ;

Egashira, Nobuaki ;

Iwasaki, Katsunori ;

Fujiwara, Michihiro .

STROKE, 2008, 39 (03) :951-958

[9]

Hiramatsu M, 1998, J PHARMACOL EXP THER, V284, P858

[10]

Reversion of muscarinic autoreceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1-13), an endogenous κ-opioid receptor agonist [J].

Hiramatsu, M ;

Murasawa, H ;

Mori, H ;

Kameyama, T .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (05) :920-926

← 1 2 3 4 →