Protective properties of non-nucleoside reverse transcriptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus Macaques with RT-SHIV

被引：43

作者：

Caron, Melanie ^{[6
]}

Besson, Guillaume ^{[6
]}

Etenna, Sonia Lekana-Douki ^{[6
]}

Mintsa-Ndong, Armel ^{[6
]}

Mourtas, Spyridon ^{[5
]}

Radaelli, Antonia ^{[4
]}

Morghen, Carlo De Giuli ^{[4
]}

Loddo, Roberta ^{[3
]}

La Colla, Paolo ^{[3
]}

Antimisiaris, Sophia G. ^{[2
,5
]}

Kazanji, Mirdad ^{[1
,6
]}

机构：

[1] Inst Pasteur, Paris, France

[2] FORTH, Inst Chem Engn & High Temp Proc, GR-26500 Patras, Greece

[3] Univ Cagliari, Dept Biomed Sci & Technol, I-09124 Cagliari, Italy

[4] Univ Milan, Dept Med Pharmacol, Milan, Italy

[5] Univ Patras, Dept Pharm, Pharmaceut Technol Lab, Patras 2050, Greece

[6] Ctr Int Rech Med Franceville, Unite Retrovirol, Franceville, Gabon

来源：

VIROLOGY | 2010年 / 405卷 / 01期

关键词：

Microbicide; MC1220; RT-SHIV; viral load; proviral load; T-cell subset; protection; liposomal gel; IMMUNODEFICIENCY-VIRUS TYPE-1; SEXUALLY-TRANSMITTED-DISEASES; VAGINAL TRANSMISSION; CONTROLLED-TRIAL; HIV-1; INFECTION; PREVENTION; MICROBICIDES; VACCINE; GEL; THERAPY;

D O I：

10.1016/j.virol.2010.06.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In the absence of an effective vaccine against HIV, it is urgent to develop an effective alternative such as a microbicide Single and repeated applications of MC1220 microbicide were evaluated in macaques First, animals were given a single application of 0 5% or 1 5% MC1220-containing liposomal gel A second group were treated with 05% MC1220 once a day for 4 days The control groups were treated by liposomal gel alone Thirty minutes after the last application, animals were challenged with RT-SHIV In the first protocol, 2 of 4 animals treated by 05% of the MC1220 and 2 of 5 treated by 1.5% were protected In the second protocol, 3 of 5 treated animals were protected and 5 of 5 controls were infected The RNA viral load at necropsy was significantly lower (p = 0 05) in treated-infected animals than in controls In both protocols, the number of CD4+ T cells was lower at viremia peak in infected than in protected animals (C) 2010 Elsevier Inc All rights reserved

引用

页码：225 / 233

页数：9

共 38 条

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