Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation

被引：136

作者：

Huang, Xiao-Jun ^{[1
]}

Liu, Dai-Hong ^{[1
]}

Liu, Kai-Yan ^{[1
]}

Xu, Lan-Ping ^{[1
]}

Chen, Huan ^{[1
]}

Han, Wei ^{[1
]}

机构：

[1] Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 03期

关键词：

donor lymphocyte infusion; relapse; haploidentical; transplantation;

D O I：

10.3324/haematol.10570

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, we tested the efficacy and safety of donor lymphocyte infusion (DLI) with granulocyte colony-stimulating factor (G-CSF) priming in patients who relapsed after haploidentical hematopoietic stem cell transplantation (HSCT). Twenty patients received DLI at a median of 177 days after HSCT. Eight patients survived in complete remission for a median of 1118 days. The 2-year probability of leukemia-free survival was 40%. Acute graft-versus-host disease (GVHD) grade 3-4 occurred in six patients after DLI. GVHD prophylaxis reduced the incidence of acute GVHD. Our primary data showed that G-CSF-primed DLI with GVHD prophylaxis was a potentially effective therapeutic option for patients who relapsed after haploidentical HSCT.

引用

页码：414 / 417

页数：4

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