The role of heme oxygenase-1 promoter polymorphisms in human disease

被引：340

作者：

Exner, M

Minar, E

Wagner, O

Schillinger, M

机构：

[1] Vienna Gen Hosp, Med Sch, Div Angiol, Dept Internal Med 2, A-1090 Vienna, Austria

[2] Vienna Gen Hosp, Med Sch, Dept Lab Med, A-1090 Vienna, Austria

[3] Vienna Gen Hosp, Med Sch, Dept Angiol, A-1090 Vienna, Austria

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 37卷 / 08期

关键词：

heme oxygenase-1; gene; polymorphism; promoter; review; free radicals;

D O I：

10.1016/j.freeradbiomed.2004.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heme oxygenase (HO) seems to be a novel protective factor with potent anti-inflammatory, anti-oxidant, and anti-proliferative effects. HO-1, the inducible isoform, is expressed in various tissues and is upregulated by multiple stimuli. However, humans differ quantitatively in their ability to mount an HO-1 response, modulated by two potentially functional polymorphisms in the HO-1 gene promoter region. From several studies it seems that the ability of a patient with certain genotypes to respond strongly in terms of upregulating HO-1 may be an important endogenous protective factor. In the present article we systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level of HO-1 expression in different organ systems. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：1097 / 1104

页数：8

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