PVA-clay nanocomposite hydrogels for wound dressing

Polymer gels as soft biomaterials have found diverse applications in biomedical field, e.g. in management and care of wound as wound dressing. The recent researches on nanocomposite materials have shown that some properties of polymers and gets significantly improve by adding organoclay into polymeric matrix. In this work, in order to obtain wound dressing with better properties, nanocomposite hydrogel wound dressing was prepared using combination of polyvinyl alcohol hydogel and organoclay, i.e. Na-montmorillonite, via the freezing-thawing method. The effect of organoclay quantity on the structural, swelling, physical and mechanical properties of nanocomposite hydrogel wound dressing was investigated. The results showed that the nanocomposite hydrogels could meet the essential requirements for the reasonable wound dressing with some desirable characteristics such as relatively good swelling, appreciated vapour transmission rate, excellent barrierity against microbe penetration and mechanical properties. The results also indicated that the quantity of the clay added to the nanocomposite hydrogel is the key factor in obtaining such suitable properties required for wound dressing. (c) 2006 Elsevier Ltd. All rights reserved.