Novel cyanoguanidines with potent oral antitumour activity

被引：54

作者：

Schou, C

Ottosen, ER

Petersen, HJ

Björkling, F

Latini, S

Hjarnaa, PV

Bramm, E

Binderup, L

机构：

[1] Leo Pharmaceut Prod, Dept Chem, DK-2750 Ballerup, Denmark

[2] Leo Pharmaceut Prod, Dept Biochem, DK-2750 Ballerup, Denmark

[3] Leo Pharmaceut Prod, Dept Pharmacol, DK-2750 Ballerup, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(97)10152-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N'-cyano-N "-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice. (C) 1997 Elsevier Science Ltd.

引用

页码：3095 / 3100

页数：6

共 10 条

[1]

AABO K, 1994, CANCER RES, V54, P3295

[2]

AABO K, 1995, EUR J CANCER, V2, P222

[3]

GATI E, 1984, INT J TISSUE REACT, V6, P43

[4] SYNTHESIS OF N-ALKYL-N'-CYANO-N''-4-PYRIDYLGUANIDINES FROM 4-PYRIDYLDITHIOCARBAMIC ACID VIA N-ALKYL-N'-4-PYRIDYLTHIOUREAS, OR VIA 4-PYRIDYLCYANIMINOTHIOCARBAMIC ACID [J].