Evaluation of LRRK2 G2019S penetrance -: Relevance for genetic counseling in Parkinson disease

被引：105

作者：

Goldwurm, S.

Zini, M.

Mariani, L.

Tesei, S.

Miceli, R.

Sironi, F.

Clementi, M.

Bonifati, V.

Pezzoli, G.

机构：

[1] Ist Clin Perfezionamento, Parkinson Inst, I-20126 Milan, Italy

[2] Ist Nazl Studio & Cura Tumori, Unit Med Stat & Biometry, Milan, Italy

[3] Fdn Osped Maggiore Policlin, Mol Genet Lab, Milan, Italy

[4] Univ Padua, Dept Pediat, I-35100 Padua, Italy

[5] Erasmus Univ, Med Ctr, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

来源：

NEUROLOGY | 2007年 / 68卷 / 14期

关键词：

D O I：

10.1212/01.wnl.0000254483.19854.ef

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

引用

页码：1141 / 1143

页数：3

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