Enantioenrichment by Iterative Retro-Aldol/Aldol Reaction Catalyzed by an Achiral or Racemic Base

被引：50

作者：

Flock, Angelika M. ^{[1
]}

Reucher, Christine M. M. ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 13期

关键词：

aldol reaction; asymmetric amplification; enantioenrichment; grinding; reversible reactions; CHIRAL-SYMMETRY-BREAKING; ATTRITION-ENHANCED DERACEMIZATION; RESOLUTION; CRYSTALLIZATION; HOMOCHIRALITY; EMERGENCE; STATE;

D O I：

10.1002/chem.200903497

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical Equation Presented Did nature use the same strategy? The combination of crystal growth and iterative retro-aldol/aldol reactions catalyzed by a simple achiral (or racemic) base allows improvement of the enantiomer ratio of a product obtained from a stereochemically imperfect aldol reaction (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3918 / 3921

页数：4

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