Spatial positioning: A new dimension in genome function

被引：124

作者：

Misteli, T ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2004年 / 119卷 / 02期

关键词：

D O I：

10.1016/j.cell.2004.09.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience distinct local environments due to the presence of chromatin domains and subnuclear compartments. Recent observations have highlighted the important yet still largely mysterious role of spatial positioning in genome activity and stability.

引用

页码：153 / 156

页数：4

共 19 条

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