Ten-Year Drug Survival of Anti-TNF Agents in the Treatment of Inflammatory Arthritides

被引：35

作者：

Biggioggero, Martina ^{[1
]}

Favalli, Ennio Giulio ^{[1
]}

机构：

[1] Gaetano Pini Inst, Dept Rheumatol, I-20122 Milan, Italy

来源：

DRUG DEVELOPMENT RESEARCH | 2014年 / 75卷

关键词：

anti-tumor necrosis factor (TNF); inflammatory arthritides; drug survival; RHEUMATOID-ARTHRITIS; REGISTRY; RATES; ANTAGONISTS; ETANERCEPT; ADALIMUMAB; INFLIXIMAB; RETENTION; REMISSION; COHORT;

D O I：

10.1002/ddr.21192

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Tumor necrosis factor (TNF) inhibitor therapies (anti-TNFs) are used routinely as first-line biotherapy for the treatment of rheumatoid arthritis (RA) and spondyloarthritis (SpA: psoriatic arthritis [PsA] and ankylosing spondylitis [AS]) in patients who have failed traditional non-biologic disease-modifying anti-rheumatic drugs (DMARDs). However, about 30% of patients experience failure of first-line anti-TNF agent because of inefficacy or adverse events. This study analyzed long-term anti-TNF drug survival in a clinical practice setting. The overall 10-year retention rate of first-line anti-TNF agent is about 23%, being significantly higher for SpA compared with RA patients. ETN is the most persistent anti-TNF with a drug survival rate significantly higher than IFX and ADA.

引用

页码：S38 / S41

页数：4

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