Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas

被引：20

作者：

Clavreul, Anne ^{[1
,2
,3
]}

Piard, Nicole ^{[4
]}

Tanguy, Jean-Yves ^{[5
]}

Gamelin, Eric ^{[6
]}

Rousselet, Marie-Christine ^{[7
]}

Leynia, Pierre ^{[6
]}

Menei, Philippe ^{[1
,2
,3
]}

机构：

[1] CHU Angers, Dept Neurochirurg, F-49933 Angers, France

[2] INSERM, U646, F-49100 Angers, France

[3] Univ Angers, UMR S646, F-49100 Angers, France

[4] EFS, Angers, France

[5] CHU Angers, Dept Radiol, F-49933 Angers, France

[6] Reg Canc Ctr CRLCC, Ctr Paul Papin, F-49933 Angers, France

[7] CHU Angers, Lab Pathol Cellulaire & Tissulaire, F-49933 Angers, France

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2010年 / 17卷 / 07期

关键词：

GM-CSF; Immunotherapy; Malignant glioma; Vaccination; COLONY-STIMULATING FACTOR; CLINICAL-TRIAL; ADOPTIVE IMMUNOTHERAPY; PEPTIDE VACCINATION; GENE-TRANSFER; PHASE-II; IMMUNIZATION; CHEMOTHERAPY; RESPONSES; THERAPY;

D O I：

10.1016/j.jocn.2009.11.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

We report on the safety and feasibility of autologous tumor cell vaccination combined with infusion of granulocyte-macrophage colony-stimulating factor by a programmable pump in the treatment of recurrent malignant gliomas The programmable pump is a promising tool used to infuse cytokines subcutaneously for vaccination Our trial enrolled nine patients who had undergone surgery, radiation and had been successfully weaned off steroids Unfortunately, only five patients completed the protocol and were monitored for side effects, local reactions, delayed-type hypersensitivity (DTH) responses and survival The treatment was well tolerated Two patients developed DTH reactions after vaccination and three patients had an unusually long survival without any other treatment Despite the few patients treated, the results of this trial are encouraging This study also highlights the specific difficulties encountered in vaccination programs for the treatment of glioma (C) 2010 Elsevier Ltd All rights reserved

引用

页码：842 / 848

页数：7

共 35 条

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