Spectroscopic approach for on-line monitoring of particle size during the processing of pharmaceutical nanoparticles

被引：58

作者：

Higgins, JP ^{[1
]}

Arrivo, SM ^{[1
]}

Thurau, G ^{[1
]}

Green, RL ^{[1
]}

Bowen, W ^{[1
]}

Lange, A ^{[1
]}

Templeton, AC ^{[1
]}

Thomas, DL ^{[1
]}

Reed, RA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, West Point, PA 19486 USA

来源：

ANALYTICAL CHEMISTRY | 2003年 / 75卷 / 08期

关键词：

D O I：

10.1021/ac0207980

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel application of near-infrared (near-IR) spectroscopy for the on-line determination of nanoparticle size of a drug compound in a high solids dispersion is described. The on-line spectroscopic technique provides real-time data for process monitoring and control and overcomes the limitations that are encountered using laboratory-based instrumentation for nanoparticle size determination. Near-IR spectroscopy is capable of providing an accuracy of 2.4 nm near the endpoint of particle production, where the volume-weighted D90 particle size is determined to be 200-220 nm. The accuracy is adequate for endpoint control, which minimizes excess processing and provides control over the particle size throughout nanoparticle production.

引用

页码：1777 / 1785

页数：9

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