Chemical double-mutant cycles: dissecting non-covalent interactions

被引：221

作者：

Cockroft, Scott L. ^{[1
]}

Hunter, Christopher A. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Ctr Chem Biol, Krebs Inst Biomol Sci, Sheffield S3 7HF, S Yorkshire, England

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 02期

关键词：

D O I：

10.1039/b603842p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

引用

页码：172 / 188

页数：17

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