Allogeneic peripheral stem cell transplantation in a case of hereditary sideroblastic anaemia

被引：12

作者：

González, MI ^{[1
]}

Caballero, D ^{[1
]}

Vázquez, L ^{[1
]}

Cañizo, C ^{[1
]}

Hernández, R ^{[1
]}

López, C ^{[1
]}

Izarra, A ^{[1
]}

Arroyo, JL ^{[1
]}

González, M ^{[1
]}

García, R ^{[1
]}

San Miguel, JF ^{[1
]}

机构：

[1] Hosp Clin Univ Salamanca, Hematol Serv, Salamanca 37007, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 109卷 / 03期

关键词：

hereditary sideroblastic anaemia; haemopoietic transplantation;

D O I：

10.1046/j.1365-2141.2000.02050.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother, By using short tandem repeat polymorphism, 100% donor cells were observed in peripheral blood on day +21; bone marrow showed mixed chimaerism from day +21 to day +221, when 100% cells of donor origin were observed. The patient developed extensive chronic graft-versus-host disease with favourable response to treatment. When the haemoglobin range was normal, a programme of phlebotomies reduced serum ferritin levels. Three years after transplantation, the patient has an ECOG rating of 0, with completely normal haemoglobin values (15 g/dl). To our knowledge, this is the first PBSCT reported in a case of hereditary sideroblastic anaemia.

引用

页码：658 / 660

页数：3

共 7 条

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