Gene therapy turns the corner

被引：20

作者：

Dick, JE

机构：

[1] Univ Toronto, Hosp Sick Children, Res Inst, Program Canc Blood, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Hosp Sick Children, Res Inst, Program Dev Biol, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5G 1X8, Canada

来源：

NATURE MEDICINE | 2000年 / 6卷 / 06期

关键词：

D O I：

10.1038/76188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies indicate that it is possible to achieve long-term gene transfer into hematopoietic stem cells and progenitor cells. But what needs to be done before we can take the final steps towards human stem cell gene therapy (pages 652–658)?

引用

页码：624 / 626

页数：3

共 11 条

[1] Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells [J].

Abonour, R ;

Williams, DA ;

Einhorn, L ;

Hall, KM ;

Chen, J ;

Coffman, J ;

Traycoff, CM ;

Bank, A ;

Kato, I ;

Ward, M ;

Williams, SD ;

Hromas, R ;

Robertson, MJ ;

Smith, FO ;

Woo, D ;

Mills, B ;

Srour, EF ;

Cornetta, K .

NATURE MEDICINE, 2000, 6 (06) :652-658

[2]

[Anonymous], 1996, B MED ETHICS

[3] The enigma of local recurrence [J].

Brennan, MF .

ANNALS OF SURGICAL ONCOLOGY, 1997, 4 (01) :1-12

[4] Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease [J].

Cavazzana-Calvo, M ;

Hacein-Bey, S ;

Basile, CD ;

Gross, F ;

Yvon, E ;

Nusbaum, P ;

Selz, F ;

Hue, C ;

Certain, S ;

Casanova, JL ;

Bousso, P ;

Le Deist, F ;

Fischer, A .

SCIENCE, 2000, 288 (5466) :669-672

[5] INTRODUCTION OF A SELECTABLE GENE INTO PRIMITIVE STEM-CELLS CAPABLE OF LONG-TERM RECONSTITUTION OF THE HEMATOPOIETIC SYSTEM OF W/WV MICE [J].

DICK, JE ;

MAGLI, MC ;

HUSZAR, D ;

PHILLIPS, RA ;

BERNSTEIN, A .

CELL, 1985, 42 (01) :71-79

[6]

GUENECHEA G, IN PRESS MOL THER

[7] Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells [J].

Hanenberg, H ;

Xiao, XL ;

Dilloo, D ;

Hashino, K ;

Kato, I ;

Williams, DA .

NATURE MEDICINE, 1996, 2 (08) :876-882

[8] High-efficiency retroviral transduction of mammalian cells on positively charged surfaces [J].

Hennemann, B ;

Chuo, JY ;

Schley, PD ;

Lambie, K ;

Humphries, RK ;

Eaves, CJ .

HUMAN GENE THERAPY, 2000, 11 (01) :43-51

[9]

KLEM HP, 1998, BLOOD, V92, P1878

[10] Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy [J].

Larochelle, A ;

Vormoor, J ;

Hanenberg, H ;

Wang, JCY ;

Bhatia, M ;

Lapidot, T ;

Moritz, T ;

Murdoch, B ;

Xiang, LX ;

Kato, I ;

Williams, DA ;

Dick, JE .

NATURE MEDICINE, 1996, 2 (12) :1329-1337

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