Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia

被引：60

作者：

Byrne, M ^{[1
]}

Clafferty, BA ^{[1
]}

Cosway, R ^{[1
]}

Grant, E ^{[1
]}

Hodges, A ^{[1
]}

Whalley, HC ^{[1
]}

Lawrie, SM ^{[1
]}

Owens, DGC ^{[1
]}

Johnstone, EC ^{[1
]}

机构：

[1] Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland

来源：

JOURNAL OF ABNORMAL PSYCHOLOGY | 2003年 / 112卷 / 01期

关键词：

D O I：

10.1037/0021-843X.112.1.38

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Neuropsychological assessments were compared among individuals at enhanced genetic risk of schizophrenia (n = 157) and controls (n = 34). The relationship between cognitive impairments and the presence of psychotic symptoms and measures of genetic risk was explored in the high-risk subjects. Neuropsychological differences were identified in many areas of function and were not accounted for by the presence of psychotic symptoms. Genetic liability was not associated with neuropsychological performance or with psychotic symptoms, but exploratory analysis showed Some tests were associated with both liability measures. These results suggest that what is inherited is not the disorder itself but a state of vulnerability manifested by neuropsychological impairment, occurring in many more individuals than are predicted to develop the disorder.

引用

页码：38 / 48

页数：11

共 69 条

[1]

Aleman A, 1999, AM J PSYCHIAT, V156, P1358

[2]

[Anonymous], 1974, MEASUREMENT CLASSIFI

[3]

[Anonymous], 1992, ICD 10 CLASS MENT BE

[4] CHILDREN AT RISK FOR SCHIZOPHRENIA - CONVERGING LINES OF EVIDENCE [J].

ASARNOW, JR .

SCHIZOPHRENIA BULLETIN, 1988, 14 (04) :613-631

[5] INTELLIGENCE IN SCHIZOPHRENIA - META-ANALYSIS OF THE RESEARCH [J].

AYLWARD, E ;

WALKER, E ;

BETTES, B .

SCHIZOPHRENIA BULLETIN, 1984, 10 (03) :430-459

[6] THE SPOT-THE-WORD TEST - A ROBUST ESTIMATE OF VERBAL INTELLIGENCE BASED ON LEXICAL DECISION [J].

BADDELEY, A ;

EMSLIE, H ;

NIMMOSMITH, I .

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 1993, 32 :55-65

[7]

Baddeley A., 1992, The Speed and Capacity of Language-Processing test

[8]

BOX GEP, 1949, BIOMETRIKA, V36, P317, DOI 10.1093/biomet/36.3-4.317

[9] Epidemiology and natural history of schizophrenia [J].

Bromet, EJ ;

Fennig, S .

BIOLOGICAL PSYCHIATRY, 1999, 46 (07) :871-881

[10] Response suppression, initiation and strategy use following frontal lobe lesions [J].

Burgess, PW ;

Shallice, T .

NEUROPSYCHOLOGIA, 1996, 34 (04) :263-272

← 1 2 3 4 5 6 7 →