Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats

被引:39
作者
Hansen, MK [1 ]
Kapás, L [1 ]
Fang, JD [1 ]
Krueger, JM [1 ]
机构
[1] Univ Tennessee, Ctr Hlth Sci, Dept Physiol & Biophys, Memphis, TN 38163 USA
关键词
feeding; vagal nerve; non-rapid eye movement sleep; rapid eye movement sleep; brain temperature; electroencephalographic slow-wave activity;
D O I
10.1152/ajpregu.1998.274.1.R168
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Feeding rats a cafeteria diet results in increased food intake and excess sleep. Furthermore, vagal afferent activity is altered by a variety of gastrointestinal factors, and vagal stimulation can induce sleep. We investigated, therefore, the hypothesis that the vagal nerve plays a critical role in mediating the sleep-inducing effects of cafeteria feeding. We examined the effects of a cafeteria diet on sleep, electroencephalographic (EEG) slow-wave activity (SWA), and brain temperature (T-br) in control and vagotomized rats. EEG, electromyogram, and T-br were recorded for 7 consecutive days. Day 1 was considered a baseline day; normal rat chow was available ad libitum. On days 2-4, the animals were fed, in addition to normal chow a mixed, energy-rich diet (cafeteria diet). On days 5-7, the rats were again fed only normal rat chow. In control rats, the cafeteria diet resulted in an increase in non-rapid eye movement sleep (NREMS), which was the result of a significant lengthening of the NREMS episodes. In contrast, feeding vagotomized rats the cafeteria diet resulted in a decrease in NREMS. Cafeteria feeding decreased REMS and EEG SWA and increased T-br in both control and vagotomized rats. These results suggest that an intact vagus plays a key role in the NREMS-inducing effects of the cafeteria diet.
引用
收藏
页码:R168 / R174
页数:7
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